Female Sex, a Major Risk Factor for Salt-Sensitive Hypertension

Female sex hormones protect against salt-sensitive hypertension but not essential hypertension.

Initial studies found that female Dahl salt-sensitive (DS) rats exhibit greater blood pressure (BP) salt sensitivity than female spontaneously hypertensive rats (SHR). On the basis of the central role played by NO in sodium excretion and BP control, we further tested the hypothesis that blunted increases in BP in female SHR will be accompanied by greater increases in renal inner medullary nitri...

Ovariectomy augments hypertension in aging female Dahl salt-sensitive rats.

The ovariectomized (OVX) Dahl salt-sensitive (DS) rat fed a low-salt diet is a model of postmenopausal hypertension. In addition to estrogen loss, aging can also contribute to postmenopausal hypertension. We hypothesized that: (1) female DS rats on a low-salt diet become hypertensive with age; (2) ovariectomy accelerates age-dependent hypertension in the DS rat caused by estrogen depletion; and...

Salt-sensitive hypertension: food for thought.

E pidemiological studies demonstrating an increase in cardiovascular disease in adult children born of women who suffered nutritional privation during World War II led to many subsequent studies, demonstrating that diverse conditions leading to intrauterine growth retardation had similar effects on cardiovascular disease including hypertension. 1 Relatively mild maternal protein deficiency lead...

Salt Sensitive Hypertension and Orexin

Patients With Salt-Sensitive Hypertension

Twenty-two patients with normal plasma renln and essential hypertension were classified as "salt-sensitive" (SS) (n=9) or "non-salt-sensitive" (NSS) (n=13) from an increase in mean blood pressure with changes in sodium intake from 25 to 250 meq/day. With the high sodium diet, the SS patients gained more weight (/?<0.05), retained more sodium (/><0.05), and had a greater increase in cardiac outp...